Fusion protein comprising glutathione-s-transferase and protein having binding affinity target cell or target protein, and use thereof
AssigneeUnist (Ulsan National Institute of Science and Technology)
InventorsJa Hyoung Ryu, Joon Yong Oh, Han Sol Kim, Chae Kyu Kim, Se Byung Kang
Life of this patent
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Abstract
Provided are a fusion protein including glutathione-S-transferase and a protein having binding affinity for a target cell or a target protein, and use thereof as a drug delivery carrier and a pharmaceutical composition. The fusion protein and the drug delivery carrier including the same according to an aspect may sustain an in vivo residence time, and may also have improved target cell-targeting ability, and thus may be effectively delivered to target cells. Accordingly, it may be usefully applied to a targeted therapeutic agent.
Claims12
A drug delivery carrier comprising:
- glutathione-S-transferase (GST);
- an affibody, which is a protein having binding affinity for a target cell or a target protein;
- a linker that links the GST with the protein having binding affinity for a target cell or a target protein;
- and
- a drug bound with the GST via glutathione (GSH).
A pharmaceutical composition for preventing or treating cancer, the pharmaceutical composition comprising:
- glutathione-S-transferase (GST);
- an affibody, which is a protein having binding affinity for a target cell or a target protein;
- a linker that links the GST with the protein having binding affinity for a target cell or a target protein;
- and
- an anticancer agent bound with the GST via glutathione (GSH).
A method of delivering a drug to an individual, the method comprising administering a composition comprising glutathione-S-transferase (GST);
- an affibody, which is a protein having binding affinity for a target cell;
- a linker that links the GST with the protein having binding affinity for a target cell;
- and a drug bound with the GST via glutathione (GSH) to an individual in need thereof.
A method of preventing or treating cancer, the method comprising administering a composition comprising glutathione-S-transferase (GST);
- an affibody, which is a protein having binding affinity for a target cell;
- a linker that links the GST with the protein having binding affinity for a target cell;
- and an anticancer agent bound with the GST via glutathione (GSH) to an individual in need thereof.
Dependencies are inferred from the claim text.