Back to results
US 11,844,807 B2Granted
Methods of manufacturing microspheres
AssigneeApplaud Medical, Inc.
InventorsDaniel J. Laser, Alice Luong, Robert G. Miotke
Life of this patent
Estimating the term…
Abstract
The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.
Claims19
A method of manufacturing microspheres, the method comprising the steps of:
- (a) preparing a formulation for making microspheres comprising:
- a compound of Formula I
- or a salt, isomer, or salt of an isomer thereof;
- wherein:
- n is from 10 to 30,
- m is from 1 to 100, and
- X is selected from the group consisting of:
- hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, OH, SO3H and PO3H;
- at least one pharmaceutically acceptable excipient or water;
- (b) combining in a vessel (i) the formulation of step (a) and (ii) a fluid having a normal boiling point of less than 30° C.;
- (c) agitating the vessel containing the formulation and fluid from step (b);
- and
- (d) obtaining the produced microspheres.
10 more elements
Dependencies are inferred from the claim text.