US 11,841,351 B2 · Sample analysis apparatus · patentgrep

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Abstract

A response factor that is a signal strength ratio with respect to a reference compound for various compounds is previously stored in a response factor storage (22). When an operator instructs to estimate an analysis limit value, a measurement unit (1) performs GC-MS analysis on a sample containing the reference compound a plurality of times under control of an analysis controller (3). A signal strength calculator (23) obtains a signal strength value of the reference compound based on an analysis result of the measurement unit (1), a relative strength calculator (24) calculates a relative standard deviation from the plurality of measured signal strength values, and calculates the relative standard deviation of a target compound from the response factor of the target compound read from the response factor storage (22). An analysis limit value estimator (25) estimates a limit of detection (LOD) and the like from the relative standard deviation of the target compound by a known method, and displays the LOD on a display (6). Consequently, the analysis limit value can simply be obtained without actually measuring the target compound.

Claims18

Dependent claims

A sample analysis apparatus configured to analyze various substances contained in a sample, the sample analysis apparatus comprising:

a processor that comprises a response factor storage in which response factors are stored for various substances, a response factor being a signal strength ratio of at least one kind of concentration of one of the various substances and a reference substance having an identical or different concentration;
and
an analysis controller configured to control the sample analysis apparatus so as to measure the reference substance to obtain a signal strength value;
wherein the processor is configured to:
estimate one of the signal strength, an SN ratio, and a relative standard deviation during repeated analysis based on the measured signal strength value for the reference substance obtained under the control of the analysis controller and the response factor for a target substance stored in the response factor storage;
and
calculate an analysis limit value of the target substance using one of the signal strength, the SN ratio, and the relative standard deviation.

4 more elements

A sample analysis apparatus configured to analyze various substances contained in a sample, the sample analysis apparatus comprising:

a processor that comprises a response factor storage in which response factors are stored for various substances, a response factor being a signal strength ratio of at least one kind of concentration of one of the various substances and a reference substance having an identical or different concentration;
and
an analysis controller configured to control the sample analysis apparatus so as to measure the reference substance and a blank sample to obtain signal strength values;
wherein the processor is configured to:
prepare a calibration curve for a target substance based on the measured signal strength value for the reference substance obtained under the control of the analysis controller and the response factor for the target substance stored in the response factor storage;
and
calculate an analysis limit value of the target substance using the measured signal strength value for the blank sample obtained under the control of the analysis controller and the calibration curve for the target substance obtained by the processor.

4 more elements

A sample analysis apparatus configured to analyze various substances contained in a sample, the sample analysis apparatus comprising:

a processor that comprises a response factor storage in which response factors are stored for various substances, a response factor being a signal strength ratio of at least one kind of concentration of one of the various substances and a reference substance having an identical or different concentration;
and
an analysis controller configured to control the sample analysis apparatus so as to measure the reference substance to obtain a signal strength value;
wherein the processor is configured to:
prepare a calibration curve for a target substance based on the measured signal strength value for the reference substance obtained under the control of the analysis controller and the response factor for the target substance stored in the response factor storage;
and
calculate an analysis limit value of the target substance based on a slope of the calibration curve for the target substance obtained by the processor and a standard deviation of a residual of the calibration curve calculated from the calibration curve.

4 more elements

A sample analysis apparatus configured to analyze various substances contained in a sample, the sample analysis apparatus comprising:

a processor that comprises a response factor storage in which response factors are stored for various substances, a response factor being a signal strength ratio of at least one kind of concentration of one of the various substances and a reference substance having an identical or different concentration;
and
an analysis controller configured to control the sample analysis apparatus so as to measure the reference substance to obtain a signal strength value;
wherein the processor is configured to:
prepare a calibration curve for a target substance based on the measured signal strength value for the reference substance obtained under the control of the analysis controller and the response factor for the target substance stored in the response factor storage;
and
calculate an analysis limit value of the target substance based on a slope of the calibration curve for the target substance obtained by the processor and a standard deviation of a residual of a y-intercept obtained from the calibration curve.

4 more elements

A sample analysis apparatus configured to analyze various substances contained in a sample, the sample analysis apparatus comprising:

a processor that comprises a response factor storage in which response factors are stored for various substances, a response factor being a signal strength ratio of at least one kind of concentration of one of the various substances and a reference substance having an identical or different concentration;
and
an analysis controller configured to:
control the sample analysis apparatus so as to measure the reference substance to obtain a signal strength value;
and
control the sample analysis apparatus to obtain a noise level of the sample analysis apparatus during the analysis of the reference substance or at a timing different from the analysis of the reference substance;
wherein the processor is configured to:
prepare a calibration curve for a target substance based on the measured signal strength value for the reference substance obtained under the control of the analysis controller and the response factor for the target substance stored in the response factor storage;
and
calculate an analysis limit value of the target substance using the measured noise level obtained under the control of the analysis controller and the calibration curve for the target substance obtained by the processor.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/606,517Filed 25 Apr 2017
Published: US 2021/0116429 A122 Apr 2021
Granted: 12 Dec 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

G01N 30/72
Detectors specially adapted therefor: mass spectrometers
G01N 30/8665
Signal analysis: for calibrating the measuring apparatus
G01N 27/623
Ion mobility spectrometry: combined with mass spectrometry
G01N 30/28
Conditioning of the fluid carrier; Flow patterns: control of physical parameters of the fluid carrier

Family

US 2021/0116429 A1Pre-grant publication · published 22 Apr 2021
US 11,841,351 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Citations

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