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US 11,840,706 B2Granted
Composition and method for generating a desired cell type and/or tissue type from hair follicular stem cells
OwnerConradus Ghosal Ghoinventor
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OwnerConradus Ghosal Ghoinventor
Estimating the term…
The present invention is concerned with a composition and in vitro method for generating a desired cell type and/or tissue type from hair follicular stem cells. The composition and in vitro method are particularly suitable for generating an autologous desired cell type and/or tissue type. Furthermore, the composition and method are especially efficient and suitable for use in the context of cosmetic cell and/or tissue transplantation in recipient areas of a subject experiencing cell and/or tissue loss caused by, for example, a wound, scar, burn injury, tissue degeneration, and aging. The composition and in vitro method are also suitable to circumvent complications related to infections and/or immune rejection of a cosmetic cell and/or tissue implant or graft.
A method for differentiating at least one hair follicular stem cell specifically into keratinocytes, said method involving contacting at least one hair follicular stem cell with a composition wherein the one physiologically acceptable vanadium compound enhances proliferation of keratinocytes comprising at least one physiologically acceptable vanadium compound, at least one antioxidant compound, at least one stem cell enhancer compound, at least one extracellular matrix compound, and at least one differentiation inducing factor, wherein the one physiologically acceptable vanadium compound is bis(maltolato)oxovanadium in a concentration of 0.01-100 mg/ml, and the stem cell enhancer compound is erythropoietin, and the one differentiation inducing factor is epithelial growth factor, to thereby obtain keratinocytes.
Dependencies are inferred from the claim text.