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US 11,840,686 B2Granted
Modulation of prekallikrein (PKK) expression
AssigneeIonis Pharmaceuticals, Inc.
InventorsSusan M. Freier, Huynh-Hoa Bui
Life of this patent
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Abstract
Disclosed herein are antisense compounds and methods for decreasing PKK mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate PKK-associated diseases, disorders, and conditions.
Claims21
A compound comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides, wherein the modified oligonucleotide has a nucleobase sequence comprising at least 15 contiguous nucleobases of the nucleobase sequence of SEQ ID NO:
- 131 or the nucleobase sequence of SEQ ID NO:
- 1670.
Dependencies are inferred from the claim text.