Modulators of Mas-related G-protein receptor X4 and related products and methods
AssigneeEscient Pharmaceuticals, Inc.
InventorsAdam Yeager, Brandon Selfridge, Marcos Sainz, Esther Martinborough, Marcus Boehm, Liming Huang
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Abstract
Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4 dependent condition more specifically, by contacting the MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein n, x, A, Q1, Q2, Z, R, R1, R2, R3, R4 and R5 are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.
Claims32
A method for modulating a Mas-Related G-Protein Receptor (MRGPR) X4 by contacting the MRGPRX4 with an effective amount of a compound having one of the following structures, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:
- Cpd No.
- Structure
- 1-55
- 1-78
- 5-1
- 4-10
- 1-65
- 4-11
- 1-58
- 1-56
- 9-1
- 1-82
- 1-85
- 1-29
- 1-101
- 2-3
- 1-103
- 1-112
- 4-7
- 11-1
A method for treating an Mas-Related G-Protein Receptor (MRGPR) X4 dependent condition by administering to a subject in need thereof an effective amount of a compound having one of the following structures, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:
- Cpd No.
- Structure
- 1-55
- 1-78
- 5-1
- 4-10
- 1-65
- 4-11
- 1-58
- 1-56
- 9-1
- 1-82
- 1-85
- 1-29
- 1-101
- 2-3
- 1-103
- 1-112
- 4-7
- 11-1
Dependencies are inferred from the claim text.