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US 11,840,514 B2Granted
Catalysts and methods for enantioselective conjugate addition of amines to unsaturated electrophiles
AssigneeNorthwestern University
InventorsKarl A. Scheidt, Brice Uno
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Abstract
Disclosed are complexes and methods of using the complexes as catalysts for addition of amines to unsaturated electrophiles, as well as novel compounds produced by the disclosed complexes and methods. The disclosed methods may utilize the disclosed complexes as catalysts for adding unprotected primary amines and secondary amines to unsaturated electrophiles in an enantioselective manner to produce novel compounds which may include amino substituted succinimide compounds.
Claims7
A compound of a formula:
- wherein
- R1 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, and —CH2—R1 ,
- wherein R1′ is selected from the group consisting of aryl, arylalkyl, and cycloalkyl, and
- R1′ is optionally substituted at one or more positions with alkyl, halo, or alkoxy;
- R2 is hydrogen or alkyl;
- and
- R3 is hydrogen, alkyl, alkoxy, or halo.
4 more elements
Dependencies are inferred from the claim text.