Back to results
US 11,840,446 B2Granted
Fabrication of 3D microelectrodes and use thereof in multi-functional biosystems
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsSwaminathan Rajaraman, Charles Didier, Avra Kundu
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a microelectrode platform that may be used for multiple biosystem applications including cell culturing techniques and biosensing. Also disclosed are microfabrication techniques for inexpensively producing microelectrode platforms.
Claims14
A method of fabricating micromilled microneedles from a planar substrate, the method comprising
- micromilling a plurality of cut-outs onto the planar substrate, the cut-outs each comprising a cut electrode portion and an intact region that is intact with the planar sheet;
- and
- transitioning material at the plurality of the cut-outs such that the material extends orthogonal to the planar substrate,
- wherein the transitioning step comprises
- (i) aligning an array of transition-effecting structures with the planar substrate such that individual transition-effecting structures are oriented with the plurality of cut-outs, the array of transition-effecting structures comprising elongated bodies;
- and
- (ii) inserting the array of transition-effecting structures through the planar substrate to bend the cut electrode portion of the cut-outs about the intact region such that the cut electrode portion is out of plane with the planar substrate.
4 more elements
A 3D MEA platform comprising
- a 3D printed substrate;
- one or more conductive traces deposited on the 3D printed substrate;
- one or more microneedles disposed suprajacent to the one or more traces, wherein the microneedles are comprised of cut-outs in a planar substrate, the cut-outs each comprising a cut electrode portion and an intact region with the cut electrode portion being bent about the intact region so as to be out of plane with the planar substrate;
- an insulation layer disposed on to the microneedles;
- and
- a culture well disposed suprajacent to the insulation layer, wherein the microneedles protrude through the insulation layer into the culture well.
3 more elements
Dependencies are inferred from the claim text.