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US 11,839,487 B2Granted
Ophthalmic drug delivery
AssigneeEyenovia, Inc.
InventorsBernard L. Ballou, Jr., Mark Packer, Russell John Mumper, Tsontcho Ianchulev
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Abstract
The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Claims6
A method of delivering droplets to a surface of an eye of a subject in need thereof, the method comprising:
- (a) generating the droplets via a piezoelectric actuated ejection device, wherein:
- (i) the droplets:
- (ia) comprise an ophthalmic composition comprising tropicamide and phenylephrine hydrochloride;
- (ib) have a total volume of 5 μl to 10 μl;
- (ic) have a an average droplet size from 30 microns to 100 microns;
- and
- (id) have an average initial electing velocity from 1 m/s to about 5/ms;
- and
- (ii) the piezoelectric actuated ejection device comprises a housing;
- a reservoir containing the ophthalmic composition disposed within the housing;
- and an ejector mechanism fluidly coupled to the reservoir, the ejector mechanism comprising an ejector plate comprising a plurality of openings formed through its thickness, and a piezoelectric actuator coupled to the ejector plate, the actuator being operable to oscillate the ejector plate at a frequency to generate the droplets from the composition upon actuation;
- and
- (b) delivering the droplets to the surface of the eye of the subject.
10 more elements
Dependencies are inferred from the claim text.