Liquid chromatography analyte reaction and analysis system
AssigneeActivated Research Company, LLC
InventorsAndrew Jones, Tommy Saunders, Mike Hofflander
Life of this patent
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Abstract
In the present system and method, a conduit from a LC device continuously transports solvent, buffers, and analytes to the inlet of a solvent removal and analyte conversion device which evaporates the solvents, leaving non-volatile analytes for detection. The device comprises a rotating disk. The liquid chromatograph device can be any device using liquid chromatography to separate molecules. The solvents in the LC effluent can include, but are not limited to, water, methanol, acetonitrile, tetrahydrofuran, and acetone. After removal of the volatile components, the non-volatile analytes are converted with a concentrated energy source so that they may be detectable.
Claims18
A system for the detection and quantification of organic molecules from a liquid chromatograph comprising:
- a liquid chromatograph having an outlet;
- a device comprising a heated rotating disk, an inlet for effluent from the liquid chromatograph with the inlet situated to deposit the effluent onto a disk substrate at a location away from an edge, a solvent vent for capturing volatilized gases, an inlet for a gas, a laser as a source of concentrated energy, and a vent for receiving transformed analyte from action of the concentrated energy;
- a conduit connecting the outlet of the chromatograph with the inlet on the device for receiving effluent from the chromatograph;
- a detector for detecting and quantifying organic molecules, the detector having an inlet;
- and
- a conduit connecting the vent in the device for receiving transformed analyte to the inlet of the detector.
A method for the detection and quantification of organic molecules from a liquid chromatograph, comprising:
- providing an effluent from a liquid chromatograph;
- depositing the effluent on a substrate of a heated rotating disk at a location away from an edge of the disk;
- volatilizing gases from the effluent and leaving behind non-volatilized analytes;
- moving the analytes on the disk by rotation to a station comprising a laser as a source of concentrated energy which acts on the analytes to convert the analytes to a detectable form;
- and
- passing converted analytes to a detector for detection and quantification.
A device for removing volatile gases from a liquid to obtain a non-volatile portion, and transforming the non-volatile portion, comprising:
- a heated rotating disk, an inlet for the liquid with the inlet depositing the liquid onto a substrate of the disk at a location away from an edge of the disk, a vent for capturing volatilized gases, an inlet for gases, and a laser as a source of concentrated energy for transforming the non-volatile portion.
Dependencies are inferred from the claim text.