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US 11,834,757 B2Granted
HLA homozygous induced pluripotent stem cell (iPSC) libraries
AssigneeNew York Blood Center, Inc.
InventorsPablo Rubinstein, Christopher D. Hillyer
Life of this patent
Estimating the term…
Abstract
The present specification provides libraries of HLA homozygous induced pluripotent cell lines.
Claims20
A library of HLA homozygous induced pluripotent stem cell (iPS) lines, the library comprising:
- at least 20 different iPS cell lines homozygous for alleles at HLA-A, -B, and -DR loci, each cell line expressing a different homozygous haplotype, wherein the at least 20 iPS cell lines each have a haplotype selected from:
- HLA-A*
- HLA-B*
- HLA-DRB1*
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- wherein each of the iPS cell lines has been reprogrammed into pluripotentiality by means of non-endogenous transcription factors.
89 more elements
Dependencies are inferred from the claim text.