Recombinant cytomegalovirus vectors as vaccines for tuberculosis
AssigneesInternational AIDS Vaccine Initiative, Oregon Health & Science University
InventorsThomas G. Evans, Ravi Anantha, Aurelio M. Bonavia, Dominick J. Laddy, Louis Picker, Scott Hansen, Guangwu Xu
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Abstract
Disclosed herein are cytomegalovirus vectors encoding fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the same, cytomegalovirus vectors comprising nucleic acid molecules, compositions comprising the same, and methods of eliciting an immune response against tuberculosis.
Claims23
A recombinant rhesus cytomegalovirus (RhCMV) or human cytomegalovirus (HCMV) vector comprising a nucleic acid sequence encoding an expressible Mycobacterium tuberculosis (Mtb) antigen, wherein said Mtb antigen is a fusion protein comprising:
- a) a tripeptide consisting of the proteins Ag85A, Ag85B, and Rv3407, or fragments thereof, wherein the proteins, or fragments thereof, are joined in the order Ag85A-Ag85B-Rv3407 to form the tripeptide;
- or b) a dipeptide consisting of the proteins Ag85B and ESAT6, or fragments thereof, wherein the proteins, or fragments thereof, are joined in the order Ag85B-ESAT6 to form the dipeptide.
Dependencies are inferred from the claim text.