Bispecific antigen binding molecules that bind leptin receptor and/or GP130, and methods of use thereof

A bispecific antibody or antigen-binding fragment thereof which is a product of a method comprising:

• introducing one or more polynucleotides encoding:
• (a) a first immunoglobulin heavy chain variable region (HCVR) and a first immunoglobulin light chain variable region (LCVR) that binds human GP130, wherein said first HCVR comprises three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) from a HCVR comprising the amino acid sequence of SEQ ID NO:
• 154 and said first LCVR comprises three light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3) from a LCVR comprising the amino acid sequence of SEQ ID NO:
• 10;
• and
• (b) a second HCVR and a second LCVR that binds human leptin receptor (LEPR);
• into a host cell;
• culturing the host cell under conditions favorable to expression of the polynucleotide(s);
• and
• optionally, isolating the antibody or antigen-binding fragment from the host cell and/or medium in which the host cell was grown.