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US 11,834,470 B2Granted
4-thioribose NAD analogues and methods of synthesizing and using the same
AssigneeUniversity of Southern California
InventorsYong Zhang, Zhefu Dai, Xiao-Nan Zhang
Life of this patent
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Abstract
This disclosure provides a method of synthesis of 4′-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4′-thioribose NAD+ and compounds related thereto.
Claims15
A method of synthesizing a compound of formula I:
- or a pharmaceutically acceptable salt or solvate thereof, comprising the step of enzymatically converting a compound of formula IV:
- to the compound of formula I.
A method of inhibiting enzymatic activity of CD38, comprising contacting CD38 with a compound of formula I or pharmaceutically acceptable salts and solvates thereof:
A compound of formula I-A and pharmaceutically acceptable salts and solvates thereof:
- wherein R3 is selected from thymine, cytosine, adenine, uracil or guanine.
Dependencies are inferred from the claim text.