Treating and preventing diseases by modulating cell mechanics

A method of treating cancer in a subject comprising administering to a subject having cancer that expresses nonmuscle myosin IIB, nonmuscle myosin IIC, or a combination thereof in a subject a pharmaceutical composition comprising an agent selected from the group comprising a salt, solvate or stereoisomer of compound (VIII):

• wherein X, Y, and Z can independently be N or C, with the proviso that X, Y, and Z cannot all be N, and wherein R1 is H, OH, Halo, cyano, nitro, C1-C6 alkyl, carboxy C1-C6 alkyl, dicarboxy C1-C6 alkyl, NR2R3, wherein R2 and R3 are independently represent hydroxy, C1 to C10 alkyl, alkylamino, alkenyl, alkynyl, hydroxyalkyl, alkoxy, dialkylamino thioalkyl, thioalkenyl, thioalkynyl, aryloxy, acyloxy, thioacyl, amido, and sulphonamido, and wherein X′ is independently represent H, OH, R7, OR7, NR7R8, wherein R7 and R8 are independently C1-C6 alkyl, carboxy C1-C6 alkyl, dicarboxy C1-C6 alkyl, aryl, heteroaryl, alkenyl, alkynyl, hydroxyalkyl, alkoxy, dialkylamino thioalkyl, thioalkenyl, thioalkynyl, aryloxy, acyloxy, thioacyl, amido, or sulphonamido;
• and
• activating nonmuscle myosin IIB, nonmuscle myosin IIC, or a combination thereof, and
• treating pancreatic in the subject,
• the method further comprises the step of administering a bioactive agent having a formula:

A method for modulating cell mechanics in a disease cell that expresses nonmuscle myosin IIB, nonmuscle myosin IIC, or a combination thereof in a subject comprising:

• administering to the subject, an effective amount of a pharmaceutical composition comprising an effective amount of a compound (VIII) or a salt, solvate, or stereoisomer thereof:
• wherein X, Y, and Z can independently be N or C, with the proviso that X, Y, and Z cannot all be N, and wherein R1 is H, OH, halo, cyano, nitro, C1-C6 alkyl, carboxy C1-C6 alkyl, dicarboxy C1-C6 alkyl, NR2R3, wherein R2 and R3 are independently OH, C1 to C10 alkyl, alkylamino, alkenyl, alkynyl, hydroxyalkyl, alkoxy, dialkylamino thioalkyl, thioalkenyl, thioalkynyl, aryloxy, acyloxy, thioacyl, amido, and sulphonamido, and wherein X′ is H, OH, R1, OR1, NR1Rs, wherein R1 and Rs, are independently C1-C6 alkyl, carboxy C1-C6 alkyl, dicarboxy C1-C6 alkyl, aryl, heteroaryl, alkenyl, alkynyl, hydroxyalkyl, alkoxy, dialkylamino thioalkyl, thioalkenyl, thioalkynyl, aryloxy, acyloxy, thioacyl, amido, or sulphonamido;
• administering a bioactive agent comprising a compound having a formula:
• and
• modulating cell mechanics in the subject;
• and
• wherein the disease cell is a cell from a pancreatic cancer.

A method of treating a cancer in a subject comprising:

• administering to a subject having the cancer that expresses nonmuscle myosin IIB, nonmuscle myosin IIC, or a combination thereof in a subject a pharmaceutical composition comprising an effective amount of a compound (VIII) or a salt, solvate, or stereoisomer thereof:
• wherein X, Y, and Z can independently be N or C, with the proviso that X, Y, and Z cannot all be N, and wherein R1 is H, OH, halo, cyano, nitro, C1-C6 alkyl, carboxy C1-C6 alkyl, dicarboxy C1-C6 alkyl, NR2R3, wherein R2 and R3 are independently OH, C1 to C10 alkyl, alkylamino, alkenyl, alkynyl, hydroxyalkyl, alkoxy, dialkylamino thioalkyl, thioalkenyl, thioalkynyl, aryloxy, acyloxy, thioacyl, amido, and sulphonamido, and wherein X′ is H, OH, R1, OR1, NR1Rs, wherein R1 and Rs, are independently C1-C6 alkyl, carboxy C1-C6 alkyl, dicarboxy C1-C6 alkyl, aryl, heteroaryl, alkenyl, alkynyl, hydroxyalkyl, alkoxy, dialkylamino thioalkyl, thioalkenyl, thioalkynyl, aryloxy, acyloxy, thioacyl, amido, or sulphonamido;
• administering a bioactive agent comprising a compound having a formula:
• wherein the cancer is pancreatic cancer.