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US 11,833,220 B2Granted
Artificial multi-antigen fusion protein and preparation and use thereof
AssigneesOxford Vacmedix UK Ltd., Shisong Jiang
InventorsShisong Jiang, Xiaobing Xia, Hanghai Ding
Life of this patent
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Abstract
Provided are an artificial multi-antigen fusion protein and a preparation method thereof. The fusion protein can effectively stimulate CD8+T and CD4+ T cell immunities, and can be applied to immunodiagnostics or serve as a prophylactic or therapeutic vaccine.
Claims10
A fusion protein consisting of the following structure
- Y-(A-C)n,
- wherein A is a polypeptide fragment 15-35 amino acids in length consisting of a sequence corresponding to a subsequence of a target protein amino acid sequence that is a bacterial antigen, a viral antigen, an autoimmune disease antigen, or a tumor associated antigen,
- C is a cleavage site of cathepsin S represented by Leu-Arg-Met-Lys (SEQ ID NO:
- 9),
- n is a positive integer ≥3,
- Y is absent or is a sequence represented by “Y0-B,”
- wherein Y0 is a signal peptide sequence and/or a tag sequence and
- B is absent or a cleavage site of cathepsin S represented by Leu-Arg-Met-Lys (SEQ ID NO:9), and
- the C in the C-terminal “A-C” is absent.
6 more elements
Dependencies are inferred from the claim text.