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US 11,833,204 B2Granted
Visible light-activatable nanoparticles for cancer immunotherapy and use thereof
AssigneeKorea Institute of Science and Technology
InventorsKwangmeyung Kim, In-Cheol Sun, Man Kyu Shim, Ji Woong Choi
Life of this patent
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Abstract
Disclosed are visible light-activatable antitumor self-assembled nanoparticles or antitumor immunity-inducing self-assembled nanoparticles. The self-assembled nanoparticles induce potent apoptosis in cancer cells and increase their own anticancer immunogenicity, thereby maximizing their therapeutic efficacy for cancer.
Claims7
Self-assembled nanoparticles comprising complexes in which a hydrophobic anticancer drug and a photosensitizer are bonded to one end and the other end of a central amphipathic peptide represented by Formula 1, respectively:
- (SEQ ID NO:
- 2)
- Xaa1-Arg-Arg-Gly (1)
- wherein Xaa is selected from alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, and tryptophan.
1 more element
Dependencies are inferred from the claim text.