Peptide fragments from filoviruses and their uses
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorSurender Khurana
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Abstract
Isolated peptides comprising one or more antigenic sites of filovirus glycoprotein and methods of their use and production are disclosed. Nucleic acid molecules encoding the peptides are also provided. In several embodiments, the peptides can be used to induce an immune response to filovirus glycoprotein, such as Zaire ebolavirus glycoprotein, in a subject, for example, to treat or prevent infection of the subject with the virus.
Claims12
A method for generating an immune response to ebolavirus glycoprotein (GP) in a subject, comprising administering to the subject an effective amount of a peptide to generate the immune response, wherein the peptide comprises an amino acid sequence set forth as SEQ ID NO:
- 3, and wherein the peptide is no more than 40 amino acids in length.
A method for generating an immune response to ebolavirus glycoprotein (GP) in a subject, comprising administering to the subject an effective amount of a peptide to generate the immune response wherein the peptide consists of or consists essentially of the antigenic site V.7 amino acid sequence set forth as SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.