Method for improving intestinal flora
AssigneesAmano Enzyme Inc., Hiroshima University
InventorsManabu Kuroda, Shotaro Yamaguchi, Norihisa Kato
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Abstract
A method for improving intestinal flora increases the number of beneficial bacteria such as lactic acid bacteria and Bifidobacterium to improve intestinal flora by using an enzyme. The method involves providing a protease, which is a polypeptide having an amino acid sequence shown in SEQ ID NO: 1 that can increase beneficial bacteria such as lactic acid bacteria and Bifidobacterium in intestines to exert an excellent effect of improving intestinal flora.
Claims2
A method for improving intestinal flora, comprising orally applying a protease comprising at least one of the following polypeptides (1) to (3) to a person who requires improvement of intestinal flora:
- (1) a polypeptide consisting of an amino acid sequence shown in SEQ ID NO:
- 1;
- (2) a polypeptide comprising an amino acid sequence in which one or a few amino acids are substituted, added, inserted, or deleted in the amino acid sequence shown in SEQ ID NO:
- 1, and having a protease activity equivalent to that of a polypeptide consisting of an amino acid sequence shown in SEQ ID NO:
- 1;
- and
- (3) a polypeptide comprising an amino acid sequence having 80% or more sequence identity to an amino acid sequence shown in SEQ ID NO:
- 1, and having a protease activity equivalent to that of a polypeptide consisting of an amino acid sequence shown in SEQ ID NO:
- 1,
- wherein the protease increase the number of Bifidobacteria and Lactic acid bacteria in intestines of said subject, thereby improves the intestinal flora.
Dependencies are inferred from the claim text.