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US 11,833,159 B2Granted
Non-hormonal steroid modulators of NF-kB for treatment of disease
AssigneeReveraGen BioPharma, Inc.
InventorsJohn M. McCall, Eric Hoffman, Kanneboyina Nagaraju
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-κB for the treatment or prevention of muscular wasting disease, including muscular dystrophy.
Claims12
A pharmaceutical composition comprising between 10 to 200 mg of a compound having the structural formula
- or a salt thereof,
- wherein the pharmaceutical composition is formulated for oral administration and
- wherein the compound is present in an amount effective to treat or reduce the symptoms of muscular dystrophy.
A pharmaceutical composition comprising between 5 to 500 mg of a compound having the structural formula
- or a salt thereof,
- wherein the pharmaceutical composition is formulated for oral administration and
- wherein the compound is present in an amount effective to treat or reduce the symptoms of a muscular dystrophy chosen from Duchenne muscular dystrophy, Becker muscular dystrophy, limb girdle muscular dystrophy, congenital muscular dystrophy, facioscapulohumeral muscular dystrophy, myotonic muscular dystrophy, oculopharyngeal muscular dystrophy, distal muscular dystrophy, and Emery-Dreifuss muscular dystrophy.
Dependencies are inferred from the claim text.