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US 11,828,762 B2Granted
Methods and compositions for assessing antibody specificities
AssigneeSerimmune Inc.
InventorsPatrick Sean Daugherty, Kathryn Vinaya Louise Kamath, Jack Ryan Reifert
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.
Claims28
An array comprising an array surface and at least two peptide probes, wherein each of the at least two peptide probes comprises a binding motif selected from the group consisting of:
- [RK]MRxID (SEQ ID NO:
- 104), QHxGHP (SEQ ID NO:
- 105), KxxLPED (SEQ ID NO:
- 106), [IV]LxxFGY (SEQ ID NO:
- 107, PLDxxxxIS (SEQ ID NO:
- 108), ETXIPXE (SEQ ID NO:
- 109), [VI]Nx[DE][ML]YxP (SEQ ID NO:
- 110), FLxxIGA (SEQ ID NO:
- 111), D[VI]x[MI][ILV]x[KR] (SEQ ID NO:
- 112), RxSPYx[IL]F (SEQ ID NO:
- 113), VGPRH (SEQ ID NO:
- 114), PQxQH[ED] (SEQ ID NO:
- 115), PxxGGFG (SEQ ID NO:
- 116), KxEGxxMG (SEQ ID NO:
- 117), KxxGxTxxLS (SEQ ID NO:
- 118), EMG[FW]Q (SEQ ID NO:
- 119), [VI]KxGxxDxP (SEQ ID NO:
- 120), PE[DN]ExYP (SEQ ID NO:
- 121), HYEWA (SEQ ID NO:
- 122), [HR]SNMxF (SEQ ID NO:
- 123), M[TV]GxxYE (SEQ ID NO:
- 124), Dxx[KH]ExxLL (SEQ ID NO:
- 125), RxxWx[EDA]x[IV][AR] (SEQ ID NO:
- 126, PxDxxAx[GPA][TS] (SEQ ID NO:
- 127), PDxxSxT[ARG] (SEQ ID NO:
- 128), GRExDG (SEQ ID NO:
- 129), GVPGxxxK (SEQ ID NO:
- 130), [LM]xxx[EDQ]VxxIM (SEQ ID NO:
- 131), SxxxVSGG (SEQ ID NO:
- 132), A[KR]AG[DN]K (SEQ ID NO:
- 133, F[RN]xIN[RQ] (SEQ ID NO:
- 134), YXPVXPXSY (SEQ ID NO:
- 135), KxTFPD (SEQ ID NO:
- 136), PFM[FVM]xxR (SEQ ID NO:
- 137), EFWEP (SEQ ID NO:
- 138), [FY]GALS (SEQ ID NO:
- 139), PxGTEN (SEQ ID NO:
- 140), Gx[KE]PWE (SEQ ID NO:
- 141), and D[IV]Tx[YF][WN] (SEQ ID NO:
- 142), and wherein the at least two peptide probes extend from the array surface.
37 more elements
Dependencies are inferred from the claim text.