ApoC-II mimetic peptides
AssigneesNovo Nordisk, United State of America, As Represented by the Secretary, Dept. of Health and Human Services
InventorsAlan Thomas Remaley, Soumitra Shanker Ghosh, Madhav N. Devalaraja, Chih-Hung Lo, Denis O. Sviridov, Anna Wolska
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Abstract
The disclosure provides apolipoprotein C-II (apoC-II) mimetic peptides and methods for treating hypertriglyceridemia in a patient with an effective amount of an apoC-II mimetic peptide.
Claims6
An isolated apoC-II mimetic peptide of no more than 50 amino acids, comprising from N-terminus to C-terminus a first helical domain, a hinge region comprising 3-15 amino acids, and a second helical domain, wherein the first helical domain is amphipathic, and wherein the apoC-II mimetic peptide is not a peptide of SEQ ID NO:
- 56, and wherein the hinge region comprises one or more norleucine residues.
Dependencies are inferred from the claim text.