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US 11,827,661 B2Granted
Water soluble fluorescent or colored dyes comprising conjugating groups
AssigneeSony Group Corporation
InventorsC. Frederick Battrell, Kenneth Farber, John C. Kumer, Tracy Matray, Michael VanBrunt
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Abstract
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L3, L4, L6, L7, L8, M1, M2, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
Claims13
A compound having the following structure (Ia):
- or a salt or stereoisomer thereof, wherein:
- M1 is, at each occurrence, independently a fluorescent or colored moiety comprising two or more double bonds and at least one degree of conjugation, and at least one occurrence of M1 is a fluorescent or colored moiety comprising three or more aryl or heteroaryl rings, or combinations thereof;
- L1 is, at each occurrence, independently an optional alkylene linker;
- L3 and L7 are, at each occurrence, independently alkylene linkers;
- R1 is, at each occurrence, independently H, alkyl or alkoxy;
- R2 is -L9-(L10)z-L11-Q;
- R3 is OH, SH, —NH2, alkyl, alkylether, hydroxylalkyl, aminoalkyl, hydroxylalkylether, sulfhydrylalkyl, sulfyhdrylalkylether, cyanoalkyl, —Oaralkyl, phosphate, thiophosphate, alkylphospho, alkylthiophospho, —Oalkylphospho, —Oalkylthiophospho, alkyletherphospho, alkyletherthiophospho, —Oalkyletherphospho, —Oalkyletherthiophospho phosphoalkyl, phosphoalkylether, thiophosphoalkyl, thiophosphoalkylether, —Ophosphoalkyl, —Ophosphoalkylether, —Othiophosphoalkyl or —Othiophosphoalkylether;
- R4 is, at each occurrence, independently O−, or OZ, where Z is a cation;
- R5 is, at each occurrence, independently oxo;
- L9 is an optional C1-C6 alkylene linker;
- L11 is an optional linker;
- (L10)z has one of the following structures:
- where b is an integer from 2 to 10;
- Q is sulfhydryl, disulfide, activated ester, isothiocyanate, azide, alkyne, alkene, diene, dienophile, acid halide, sulfonyl halide, phosphine, α-haloamide, biotin, amino or a maleimide;
- and
- n is an integer from 1 to 20.
13 more elements
Dependencies are inferred from the claim text.