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US 11,827,655 B2Granted
Triplet-triplet annihilation upconversion system, and compositions and methods thereof for drug delivery
AssigneeUniversity of Massachusetts
InventorsGang Han, Ling Huang
Life of this patent
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Abstract
The invention provides a novel class of materials that possess triplet-triplet annihilation upconversion, compositions and methods of preparation and use thereof. The invention also relates to use of such materials and nanoparticles, for example, in stimulus-responsive, in situ delivery of biologically active agents.
Claims16
A method for delivery of a bioactive agent to a target site, comprising
- administering to a subject in need thereof a biocompatible nanoparticle comprising:
- a triplet photosensitizer molecule and an emitter molecule, wherein the emitter molecule is an organic molecule and comprises no metallic elements;
- the triplet photosensitizer is excited by a light in red region of about 500 nm to about 600 nm or far red region of about 600 nm to about 700 nm causing an emission by the emitter molecule in the deep blue region of about 410 nm to about 550 nm;
- and
- a photolabile molecule comprising a biologically active agent, wherein the biologically active agent is releasable upon absorption of the emission by the emitter molecule, and
- irradiating the target site with a light beam in the in red region of about 500 nm to about 600 nm or far red region of about 600 nm to about 700 nm, thereby causing the release of the biologically active agent at the target site, wherein the triplet photosensitizer molecule has the structural formula (1):
- wherein
- each of R1 and R2 independently selected from the group consisting of:
- H, bromo, iodio, alkynyl, alkyl, alkenyl, azide, PEG, amino, carboxyl acid and hydroxyl;
- R3 is selected from the uv oup consisting of:
- bromo and iodio;
- R4 is an lethynyl group;
- and
- each R5 is independently selected from the group consisting of:
- H and alkyl.
12 more elements
A method for treating tumor or cancer, comprising:
- administering to a subject in need thereof an effective amount of a biocompatible nanoparticle comprising:
- a triplet photosensitizer molecule and an emitter molecule, wherein the emitter molecule is an organic molecule and comprises no metallic elements;
- the triplet photosensitizer is excited by a light in the red region of about 500 nm to about 600 nm or far red region of about 600 nm to about 700 nm causing an emission by the emitter molecule in the blue region of about 410 nm to about 550 nm;
- and
- a photolabile molecule comprising a biologically active agent wherein the biologically active agent is an antitumor or anticancer agent, wherein the antitumor or anticancer is releasable upon absorption of the emission by the emitter molecule, and irradiating the target site with a light beam in the red region of about 500 nm to about 600 nm or far red region of about 600 nm to about 700 nm, thereby causing the release of the antitumor or anticancer agent at the target site, wherein
- wherein
- each of R1 and R2 independently selected from the group consisting of:
- H, bromo, iodio, alkynyl, alkyl, alkenyl, azide, PEG, amino, carboxyl acid and hydroxyl;
- R3 is selected from the group consisting of:
- bromo and iodio,
- R4 is an arylethynyl group;
- and
- each R5 is independently selected from the group consisting of:
- H and alkyl.
11 more elements
Dependencies are inferred from the claim text.