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US 11,827,620 B2Granted
Compounds and uses thereof for detection of target molecules in a sample
AssigneeUniversite De Geneve
InventorsGianpaolo Rando, Nicolas Winssinger, Eric Lindberg, Marcello Anzola
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Abstract
The present invention relates to new profluorophores and conjugates thereof and their use for the detection of target molecule in a sample, in particular nucleic acid target molecules. The invention relates to new profluorophores and new fluorophores and methods of use thereof particularly useful in the fields of diagnostics and quality control.
Claims19
A pro-fluorophore of Formula (I):
- wherein R1 to R8, R11-R12 and R14-R15 are independently selected from hydrogen, hydroxyl, halogen, cyano, nitro, optionally substituted C1-C10 alkyl, optionally substituted amino C1-C10 alkyl, optionally substituted C1-C10 alkoxy, R13 is selected from optionally substituted C1-C10 alkyl, optionally substituted ethyl, optionally substituted propyl or optionally substituted butyl, Z is —CR16R17 wherein R16 and R17 are independently selected from hydrogen and optionally substituted C1-C6 alkyl, or any tautomer, isomer, conjugate or salts thereof.
Dependencies are inferred from the claim text.