Ubiquitin-specific peptidase 24 inhibitor, medicinal composition including the same and method of delaying or reversing multidrug resistance in cancers using the same
AssigneeNational Cheng Kung University
InventorsChien-Chung Hung, Ming-Jer Young
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Abstract
The present invention relates to a ubiquitin-specific peptidase 24 inhibitor, a medicinal composition including the same and a method of delaying or reversing multidrug resistance in cancers using the same. The USP24 inhibitor, which includes a shUSP24 RNA and/or a carbonyl substituted phenyl compound, can serve as a chemosensitizing agent for inhibiting the drug pump out, cancer sternness and genomic instability of cancer cells, thereby being applied to a medicinal composition and a method for delaying or reversing multidrug resistance in cancers.
Claims6
A ubiquitin-specific peptidase 24 (USP24) inhibitor composition, comprising:
- a short interfering nucleic acid (siNA), and a carbonyl substituted phenyl compound, wherein the siNA is a short interfering ribonucleic acid (siRNA) having a sequence listed as SEQ ID NO:1, and the carbonyl substituted phenyl compound has a structure as formula (I-3-1), (I-3-2) or (I-3-3):
A medicinal composition for delaying or reversing multidrug resistance in cancers, comprising:
- a chemotherapeutic drug;
- and
- a chemosensitizing agent comprising a USP24 inhibitor composition, wherein the USP24 inhibitor composition comprises a siRNA having a sequence listed as SEQ ID NO:1, and a carbonyl substituted phenyl compound having a structure as formula (I-3-1), (I-3-2) or (I-3-3), so as to delay or reverse multidrug resistance in a cancer cell:
Dependencies are inferred from the claim text.