Phenyl cyclohexanone derivatives and methods of making and using them
AssigneeSpirify Pharma Inc.
InventorIrving W. Wainer
Life of this patent
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Abstract
Phenyl cyclohexanone based active agents, pharmaceutical preparations containing such active agents, methods of modifying cellular activity by contacting cells with such active agents, and methods of treating various conditions by administering such active agents to a patient are described.
Claims18
A phenyl cyclohexanone compound of Formula I, a pharmaceutically acceptable salt, or a stereoisomer thereof:
- R1 is —NH2 or-OH;
- R2 is
- where Rx is Cl, Br, —OCH3, or —NH2;
- R3 is —OCH3, —CN, —SO2—NH2,
- R4 is —H, —OH, or —OCH3;
- and
- R5 is —OH, —NH2, or ═O;
- wherein R3 is not —OCH3 when R1 is —NH2, R2 is
- R4 is —H, and R5 is —OH, or —NH2.
A phenyl cyclohexanone compound of Formula I, a pharmaceutically acceptable salt, or a stereoisomer thereof:
- R1 is —NH2 or-OH;
- R2 is,
- where Rx is Cl, Br, —OCH3, or —NH2;
- R3 is —OH, —OCH3, —NH2, —CN, —SO2—NH2,
- R4 is —H, —OH, or —OCH3;
- and
- R5 is ═O.
A method of treatment comprising administering a pharmaceutical composition in accordance with claim to a patient in need of treatment for bipolar depression, major depressive disorder, Alzheimer's dementia, amyotrophic lateral sclerosis, complex regional pain syndrome (CRPS), chronic pain, or neuropathic pain.
A phenyl cyclohexanone compound of Formula I, a pharmaceutically acceptable salt, or a stereoisomer thereof:
- R1 is —NH2 or-OH;
- R2 is,
- where Rx is Cl, Br, —OCH3, or —NH2;
- R3 is —OH, —OCH3, —NH2, —CN, —SO2—NH2,
- R4 is —H, —OH, or —OCH3;
- and
- R5 is —OH, —NH2, or ═O.
Dependencies are inferred from the claim text.