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US 11,827,596 B2Granted
Thyromimetics
AssigneeAutobahn Therapeutics, Inc.
InventorsThomas von Geldern, Jean-Christophe Poupon, Bradley Backes
Life of this patent
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Abstract
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X1, X2, and R1 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
Claims10
A compound having the structure of Formula (II):
- or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein:
- X1 is lower alkyl;
- X2 is halo;
- R1a and R1b are each, independently, H, —ORa, —NRaRb, lower alkyl, lower alkenyl, lower alkynyl, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, wherein Ra and Rb are each, independently, H or lower alkyl;
- and
- wherein R1a, R1b, Ra, and Rb are each, independently, optionally substituted with one or more halo, cyano, —OR′, —NR′R″, —S(O)2R′ or —S(O)2OR′, wherein R′ and R″ are each, independently, H or lower alkyl.
3 more elements
Dependencies are inferred from the claim text.