Method for producing amino acid aminoalkyl ester or inorganic acid salt thereof

A method for producing an amino acid aminoalkyl ester or an inorganic acid salt thereof by reacting:

• a compound represented by general formula (I) shown below or a compound represented by general formula (III) shown below, or a salt thereof, and
• at least one compound selected from the group consisting of compounds represented by general formula (IV-I) shown below, compounds represented by general formula (IV-II) shown below, compounds represented by general formula (IV-III) shown below and compounds represented by general formula (IV-IV) shown below, or an inorganic acid salt thereof:
• wherein in general formula (I), R11 represents a hydrogen atom, a monovalent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms which may have a substituent, or a monovalent aromatic cyclic group having at least 6 but not more than 10 carbon atoms which may have a substituent;
• the substituent is a group selected from the group consisting of monovalent aliphatic hydrocarbon groups having at least 1 but not more than 10 carbon atoms, monovalent aromatic cyclic groups having at least 6 but not more than 10 carbon atoms, groups represented by general formula (II-1) shown below and groups represented by general formula (II-2) shown below;
• R12 represents a group selected from the group consisting of groups represented by general formula (II-1) shown below and groups represented by general formula (II-2) shown below;
• R13 represents a hydrogen atom;
• and n11 is 1,
• wherein in general formula (II-1), R21 represents a monovalent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms which may have a substituent, or a monovalent aromatic cyclic group having at least 6 but not more than 10 carbon atoms which may have a substituent;
• and
• in general formula (II-2), R22 represents a monovalent organic group;
• wherein in general formula (III), n31 is an integer of at least 2 but not more than 4;
• R31 represents an n31-valent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms which may have a substituent, or an n31-valent aromatic cyclic group having at least 6 but not more than 10 carbon atoms which may have a substituent;
• the substituent is a group selected from the group consisting of monovalent aliphatic hydrocarbon groups having at least 1 but not more than 10 carbon atoms, monovalent aromatic cyclic groups having at least 6 but not more than 10 carbon atoms, groups represented by the general formula (II-1), groups represented by the general formula (II-2), groups represented by the general formula (II-3), and groups represented by the general formula (II-4);
• R32 represents a group selected from the group consisting of groups represented by the general formula (II-1), groups represented by the general formula (II-2) and groups represented by the general formula (II-3);
• and R33 represents a hydrogen atom or a monovalent organic group,
• wherein in general formula (II-3), each of R23 and R24 independently represents a monovalent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms which may have a substituent, or a monovalent aromatic cyclic group having at least 6 but not more than 10 carbon atoms which may have a substituent;
• and
• wherein in general formula (II-4), R25 represents a hydrogen atom or a monovalent organic group,
• wherein in general formula (IV-I), Y401 represents a divalent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms or a divalent aromatic cyclic group having at least 6 but not more than 10 carbon atoms;
• and R401 represents a group selected from the group consisting of an amino group, —NHCONH2, groups represented by the general formula (II-1), groups represented by the general formula (II-2), and groups represented by the general formula (II-3),
• wherein in general formula (IV-II), each of Y402 and Y403 independently represents a divalent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms or a divalent aromatic cyclic group having at least 6 but not more than 10 carbon atoms;
• and each of R402 and R403 independently represents a group selected from the group consisting of a hydrogen, an amino group, —NHCONH2, groups represented by the general formula (II-1), groups represented by the general formula (II-2), and groups represented by the general formula (II-3), provided that R402 and R403 do not simultaneously represent a hydrogen,
• wherein in general formula (IV-III), each of Y404, Y405 and Y406 independently represents a divalent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms or a divalent aromatic cyclic group having at least 6 but not more than 10 carbon atoms;
• and each of R404, R405 and R406 independently represents at I act one a group selected from the group consisting of a hydrogen, an amino group, —NHCONH2, groups represented by the general formula (II-1), groups represented by the general formula (II-2), and groups represented by the general formula (II-3), provided that R404, R405 and R406 do not simultaneously represent a hydrogen,
• wherein in general formula (IV-IV), each of Y407, Y408, Y409 and Y4010 represents a divalent aliphatic hydrocarbon group having at least 1 but not more than 10 carbon atoms or a divalent aromatic cyclic group having at least 6 but not more than 10 carbon atoms;
• at least one of R407, R408, R409 and R4010 represents a hydroxyl group, and each of the others represents a group selected from the group consisting of a hydrogen, an amino group, —NHCONH2, groups represented by the general formula (II-1), groups represented by the general formula (II-2), and groups represented by the general formula (II-3), provided that R407, R408, R409 and R4010 do not simultaneously represent a hydrogen,
• wherein the reaction is conducted in presence of at least one acid catalyst selected from the group consisting of organic acids and inorganic acids having a normal boiling point of 0° C. or higher, and
• the inorganic acid used as an acid catalyst is at least one acid selected from the group consisting of sulfuric acid, phosphoric acid, nitric acid and boric acid.