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US 11,827,582 B2Granted
Substituted amines as disrupters of ABETA42 oligomer formation
AssigneeAcelot, Inc.
InventorsAmbuj K. Singh, Christian A. Lang
Life of this patent
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Abstract
The present disclosure provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition. One such compound is a compound of formula 120:
Claims6
A compound of Formula 120:
- or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein:
- R1 is H;
- R3 is H;
- R4 is H;
- R5 is H;
- R6 is alkynyl;
- R7 is H;
- R8 is H;
- R20 is H, alkyl, alkyl(Oaryl), alkyl(aryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R21 is H, alkyl, alkyl(Oaryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R22 is H, NR′R″, or NR′C(O)R;
- R23 is H, alkyl, alkyl(Oaryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R24 is H, alkyl, alkyl(Oaryl), alkyl(aryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R25 is H, alkyl, alkyl(Oaryl), alkyl(aryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R26 is halogen;
- R27 is H, alkyl, alkyl(Oaryl), alkyl(aryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R28 is H, alkyl, alkyl(Oaryl), alkyl(aryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R29 is H, alkyl, alkyl(Oaryl), alkyl(aryl), alkyl(heterocyclyl), alkyl(heteroaryl), alkenyl, or alkynyl;
- R is alkyl or aryl;
- R′ is H, alkyl, or aryl;
- and
- R″ is H, alkyl, or aryl.
19 more elements
Dependencies are inferred from the claim text.