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US 11,826,435 B2Granted
Conduritol aziridine derivatives and uses thereof
AssigneeUniversity of Saskatchewan
InventorsChristopher Phenix, Daniel Tesolin, Morshed Chowdhury, Shusheng Wang
Life of this patent
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Abstract
The present application relates to conduritol aziridines of Formula (I), and uses thereof, for example, of 18F-labelled derivatives thereof in positron-emission tomography (PET) imaging of β-glucocerebrosidase activity.
Claims16
A compound of Formula I(b):
- wherein
- R2 is —OC4-10alkyl;
- R3, R4 and R5 are each —OH;
- R1 is a group selected from:
- —(CH2)xCH2X,
- —(CH2)yCHX(CH2)zCH3,
- x is an integer between 1 and 20;
- y is an integer between 1 and 10;
- z is an integer between 1 and 10;
- w is an integer between 0 and 10;
- is phenyl or pyridyl;
- X is H or F;
- and
- F is 19F or 18F.
11 more elements
Dependencies are inferred from the claim text.