Bacteriophage-based vaccines and engineered bacteriophage
AssigneeAthanor Biosciences, Inc.
InventorsHossein A Ghanbari, Michael S. Lebowitz
Life of this patent
Estimating the term…
Abstract
Engineered bacteriophage and methods of forming the bacteriophage are described. Multivalent bacteriophage are described that can include multiple different exogenous polypeptides at a surface of the capsid head. Vaccines and methods of forming and using vaccines are described. A vaccine can include an engineered bacteriophage that exhibits an immunogenic exogenous polypeptide at a surface of the bacteriophage. Multivalent bacteriophage and immunogenic bacteriophage are free of nucleic acids encoding the exogenous polypeptide(s).
Claims21
An engineered bacteriophage comprising:
- a first fusion coat protein comprising a first exogenous polypeptide directly or indirectly fused to a first coat protein of a bacteriophage;
- and
- a second fusion coat protein comprising a second exogenous polypeptide directly or indirectly fused to a second coat protein of the bacteriophage;
- wherein
- the engineered bacteriophage includes a capsid head that encloses a DNA or RNA genome, and wherein
- the engineered bacteriophage is free of nucleic acid sequences encoding the first exogenous polypeptide and the second exogenous polypeptide;
- and wherein
- the first exogenous polypeptide differs from the second exogenous polypeptide and/or the first coat protein differs from the second coat protein.
A vaccine comprising an immunogenic engineered bacteriophage, the immunogenic engineered bacteriophage including a first fusion coat protein, the first fusion coat protein including a first exogenous polypeptide directly or indirectly fused to a first bacteriophage coat protein, the first exogenous polypeptide comprising a sequence that corresponds to or is derived from a first immunogenic protein of a first pathogen, wherein the immunogenic engineered bacteriophage includes a capsid head that encloses a DNA or RNA genome, and wherein the immunogenic engineered bacteriophage is free of a nucleic acid sequence encoding the first exogenous peptide.
Dependencies are inferred from the claim text.