Chlorotoxin agents and uses thereof
AssigneeEisai Co., Ltd.
InventorsSharon McGonigle, Utpal Majumder, Maarten H. D. Postema
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Abstract
The present invention provides, among other things, compositions and methods relating to detection and/or treatment cancer (e.g., one or more tumors) that expresses Neuropilin 1 (NRP1). The present invention provides methods of treating cancer that include administering a chlorotoxin agent to a subject (e.g., to a subject suffering from or susceptible to the cancer which may, in some embodiments, be a cancer that expresses NRP1). In some embodiments, a chlorotoxin agent for use in accordance with the present invention can be or comprise a chlorotoxin polypeptide and a payload moiety (e.g., as a covalent conjugate).
Claims15
A method for treating a tumor that expresses Neuropilin 1 comprising steps of:
- determining expression of Neuropilin 1 in a tumor sample from a subject, and
- administering to the subject having the tumor determined to express Neuropilin 1 a chlorotoxin agent,
- wherein the chlorotoxin agent comprises a chlorotoxin polypeptide having an amino acid sequence at least 85% identical to SEQ ID NO:
- 1,
- wherein the chlorotoxin polypeptide comprises a carboxylated C-terminal arginine residue, and
- wherein the chlorotoxin polypeptide is characterized as binding Neuropilin 1.
Dependencies are inferred from the claim text.