Back to results
US 11,826,385 B2Granted
Major histocompatibility complex-based chimeric receptors and uses thereof for treating autoimmune diseases
AssigneeJura Bio, Inc.
InventorsJulie Norville, Elizabeth Wood
Life of this patent
Estimating the term…
Abstract
Major histocompatibility complex-based chimeric receptors (MHC-CAR) for use in targeting autoreactive immune cells. Also provided herewith are genetically engineered immune cells expressing the MHC-CAR for use in treating autoimmune diseases such as multiple sclerosis.
Claims9
A major histocompatibility complex (MHC)-based chimeric receptor, comprising:
- (a) a first polypeptide, which comprises an extracellular domain of a first MHC class II, and
- (b) a second polypeptide, which comprises an extracellular domain of a beta chain of a second MHC class II,
- wherein an antigenic peptide is fused to either the first polypeptide or the second polypeptide, and
- wherein either the first polypeptide or the second polypeptide, but not both, further comprises a cytoplasmic signaling domain.
1 more element
Dependencies are inferred from the claim text.