Method for measuring water exchange across the blood-brain barrier using MRI
AssigneeUniversity of Southern California
InventorsDanny Wang, Xingfeng Shao
Life of this patent
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Abstract
A method for measuring water exchange across the blood-brain barrier includes acquiring diffusion weighted (DW) arterial spin labeling (ASL) magnetic resonance imaging (MRI) signals. The method further includes determining optimal parameters to separate labeled water in capillary and brain tissue compartments. The method further includes estimating water exchange rate across the blood-brain barrier based on the DW ASL MRI signals and the optimal parameters, using a total generalized variation (TGV) regularized single-pass approximation (SPA) modeling algorithm.
Claims18
A method for measuring water exchange across a blood-brain barrier based on diffusion weighted (DW) arterial spin labeling (ASL) magnetic resonance imaging (MRI) signals comprising:
- acquiring a plurality of diffusion weighted (DW) arterial spin labeling (ASL) magnetic resonance imaging (MRI) signals;
- determining optimal parameters to separate labeled water in capillary and brain tissue compartments;
- and
- estimating a water exchange rate across the blood-brain barrier based on the plurality of DW ASL MRI signals and the optimal parameters, using a total generalized variation (TGV) regularized single-pass approximation (SPA) modeling algorithm wherein the TGV is an enhanced framework for estimating a given arterial transit time (ATT) and the water exchange rate based on minimizing both first-order and second-order total variation (TV) for denoising the plurality of DW ASL MRI signals.
A method for measuring water exchange across a blood-brain barrier comprising:
- acquiring a plurality of diffusion weighted (DW) arterial spin labeling (ASL) magnetic resonance imaging (MRI) signals using a diffusion prepared three-dimensional (3D) gradient and spin echo (GRASE) and background suppressed pseudo-continuous arterial spin labeling (pCASL);
- determining optimal parameters to separate labeled water in capillary and brain tissue compartments including selecting at least one of optimal b values or optimal diffusion weighting values;
- and
- estimating a water exchange rate across the blood-brain barrier based on the plurality of DW ASL MRI signals and the optimal parameters, using a total generalized variation (TGV) regularized single-pass approximation (SPA) modeling algorithm wherein the TGV is an enhanced framework for estimating a given arterial transit time (ATT) and the water exchange rate (kw) based on minimizing both first-order and second-order total variation (TV) for denoising the plurality of DW ASL MRI signals.
A method for measuring water exchange across a blood-brain barrier comprising:
- acquiring a plurality of diffusion weighted (DW) arterial spin labeling (ASL) magnetic resonance imaging (MRI) signals using a diffusion prepared three-dimensional (3D) gradient and spin echo (GRASE) and background suppressed pseudo-continuous arterial spin labeling (pCASL), and by formulating diffusion gradients in bipolar pairs along at least one of slice direction or other directions and optimizing timing to minimize eddy current;
- determining optimal parameters to separate labeled water in capillary and brain tissue compartments including selecting at least one of optimal b values or optimal diffusion weighting values;
- and
- estimating a water exchange rate across the blood-brain barrier based on the DW ASL MRI signals and the optimal parameters, using a total generalized variation (TGV) regularized single-pass approximation (SPA) modeling algorithm wherein the TGV is an enhanced framework for estimating a given arterial transit time (ATT) and the water exchange rate (kw) based on minimizing both first-order and second-order total variation (TV) for denoising the plurality of DW ASL MRI signals.
Dependencies are inferred from the claim text.