Active dampening gradient proportioning valve

A gradient proportioning valve for liquid chromatography comprising:

• a plurality of inlet ports configured to receive a plurality of fluids;
• a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, wherein each of the respective actuation mechanisms is a switch valve capable of controlled switching to determine fluid proportioning;
• a control system configured to control each of the switch valves;
• a common outlet port configured to receive the fluid composition;
• and
• an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold, wherein the active fluidic dampening system is located downstream from the respective actuation mechanisms and includes an active pulse dampening actuator separate from the respective actuation mechanisms, the active pulse dampening actuator configured to actively introduce additional pressure pulses into the manifold to destructively interfere with the unwanted fluidic pressure pulses in the manifold.