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US 11,820,998 B2Granted
Porcine Thy1 gene promoter specifically expressed in neurons
AssigneeJeju National University Industry-Academic Cooperation Foundation
InventorsSe Pill Park, Young Sok Choi, Ok Hee Lee, Mi Seon Park, Young Ho Kim, Eun Young Kim, Seung Eun Lee
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Abstract
A Thy1 gene promoter specifically expressed in neurons and a recombinant vector including the Thy1 gene promoter are provided. The Thy1 gene promoter may be utilized to regulate an expression of a target gene in preparation of an animal model similar to a human.
Claims2
A method of preparing a transgenic pig comprising:
- providing a somatic cell from a pig;
- introducing an expression vector into said somatic cell to produce a genetically modified somatic cell;
- introducing said genetically modified somatic cell into an enucleated pig oocyte to produce a transgenic pig embryo;
- transplanting said transgenic pig embryo into a surrogate pig to produce a transgenic pig,
- wherein said expression vector is a recombinant expression vector, comprising:
- a Thy1 gene promoter having a base sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 4;
- and
- a mutant gene selected from the group consisting of:
- a mutant APP gene, a mutant Tau gene and a mutant PS1 gene, wherein said mutant gene is a mutant gene found in patients with familial Alzheimer's disease.
8 more elements
Dependencies are inferred from the claim text.