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US 11,820,800 B2Granted
Orthogonal protein heterodimers
AssigneeUniversity of Washington
InventorsZibo Chen, Scott Boyken, Sherry Bermeo, Robert A. Langan, David Baker
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Abstract
Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
Claims10
A designed heterodimer protein, comprising:
- (a) a monomer A polypeptide, comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 263;
- and
- (b) a monomer B polypeptide, comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 264,
- wherein the monomer A polypeptide and the monomer B polypeptide non-covalently interact to form the designed heterodimer protein.
3 more elements
A non-naturally occurring polypeptide comprising an amino acid sequence having at least 95% sequence identity to the amino acid sequence selected from the group consisting of SEQ ID NOS:
- 263-264.
Dependencies are inferred from the claim text.