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US 11,819,842 B2Granted
Method and system for buoyant separation
AssigneeAkadeum Life Sciences, Inc.
InventorsCasey Wegner, William Lloyd, Brandon H. McNaughton, Brittany MacIntyre
Life of this patent
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Abstract
A system for buoyant separation includes a separation container. Additionally or alternatively, the system can include an automated instrument, one or more processing components, and/or any other components. A method for buoyant separation can include any or all of: manipulating the separation container; adding materials to the separation container; removing materials form the separation container; otherwise processing the separation container; and/or any other processes.
Claims21
A system for collection of a set of target materials in response to a buoyant separation process, the system comprising:
- a separation container defining a set of walls and a cavity, the cavity configured to receive a set of contents, the set of contents comprising a set of buoyant particles, the set of target materials, and a set of non-target materials, wherein the set of buoyant particles is configured to bind with the set of non-target materials and float at a top layer of the set of contents;
- a drainage hole defined at an inferior region of the separation container;
- a drain stop, wherein the drain stop is configurable in a set of operation modes, the set of operation modes comprising:
- a closed configuration mode, wherein the drain stop closes the drainage hole during the closed configuration mode, thereby preventing the set of contents from exiting the separation container;
- and
- an open configuration mode, wherein the drain stop opens the drainage hole during the open configuration mode, thereby enabling the exiting of at least a portion of the set of contents from the separation container;
- a rod connected to the drain stop at a first end and connected to a cap subsystem at a second end, wherein the rod converts movement from the cap subsystem to the drainage hole;
- the cap subsystem, the cap subsystem comprising:
- a cap overlaid on a cap insert, wherein the cap:
- is configured to rotate relative to the cap insert, wherein rotation of the cap relative to the cap insert effects a change in the operation mode of the drain stop;
- and
- the cap insert separate from the cap and the separation container;
- and
- a venting subsystem, comprising:
- a first venting aperture defined by a first broad surface of the cap insert;
- and
- a second venting aperture defined by a second broad surface of the cap, wherein rotation of the cap relative to the cap insert in a first direction, wherein the first direction effects a change from the closed configuration mode to the open configuration mode, increases a height of a gap between the cap insert and the cap, thereby establishing an air path between the first venting aperture and the second venting aperture.
14 more elements
A system for collection of a set of target materials in response to a buoyant separation process, the system comprising:
- a separation container defining a set of walls and a cavity, the cavity configured to receive a set of contents, the set of contents comprising a set of buoyant particles, the set of target materials, and a set of non-target materials, wherein the set of buoyant particles is configured to bind with the set of non-target materials and float at a top layer of the set of contents;
- a drainage hole defined at an inferior region of the separation container;
- a drain stop, wherein the drain stop is configurable in a set of operation modes, the set of operation modes comprising:
- a closed configuration mode, wherein the drain stop closes the drainage hole during the closed configuration mode, thereby preventing the set of contents from exiting the separation container;
- and
- an open configuration mode, wherein the drain stop opens the drainage hole during the open configuration mode, thereby enabling the exiting of at least a portion of the set of contents from the separation container;
- a rod connected to the drain stop at a first end, and connected to a cap subsystem at a second end, wherein the rod converts movement from the cap subsystem to the drainage hole;
- the cap subsystem, the cap subsystem comprising:
- a cap overlaid on a cap insert, wherein the cap:
- is configured to rotate relative to the cap insert, wherein rotation of the cap relative to the cap insert effects a change in the operation mode of the drain stop;
- and
- the cap insert, wherein the cap insert defines a ramp feature within an interior surface of the cap insert, and wherein the cap defines a protrusion feature with an interior surface of the cap, wherein rotation of the cap relative to the cap insert in the first direction comprises travel of the protrusion feature up the ramp feature, wherein a height of the ramp is configured to effect a predetermined second height, the predetermined second height defining a height of the drain stop above the drainage hole, wherein the predetermined second height is configured to effect a predetermined range of initial drainage flow rates during the open configuration mode.
9 more elements
A method for collection of a set of target materials in response to a buoyant separation process, the method comprising:
- at a separation container defining a set of walls, a cavity, and a drainage hole at an inferior region of the separation container, receiving a set of contents, the set of contents comprising a set of buoyant particles, the set of target materials, and a set of non-target materials, wherein the set of buoyant particles is configured to bind with the set of non-target materials and float at a top layer of the set of contents;
- performing the buoyant separation process, wherein performing the buoyant separation process comprises performing a centrifugation process, wherein the centrifugation process forms a pellet comprising the set of target materials at an inferior region of the separation container;
- rotating a cap of a cap subsystem relative to a cap insert of the cap subsystem in a first direction, wherein rotation in the first direction effects a change in operation mode of a drain stop from a closed configuration mode to an open configuration mode, the drain stop arranged superior to the drainage hole, and a set of operation modes of the drain stop comprising:
- a closed configuration mode, wherein the drain stop closes the drainage hole during the closed configuration mode, thereby preventing the set of contents from exiting the separation container;
- and
- an open configuration mode, wherein the drain stop opens the drainage hole during the open configuration mode, thereby enabling the exiting of at least a portion of the set of contents from the separation container;
- wherein rotating the cap relative to the cap insert in the first direction further comprises rotating a protrusion defined at an interior surface of the cap up a ramp feature defined at an interior surface of the cap insert, wherein rotation of the cap relative to the cap insert in the first direction comprises travel of the protrusion feature up the ramp feature, wherein a height of the ramp is configured to effect a predetermined second height, the predetermined second height defining a height of the drain stop above the drainage hole, wherein the predetermined second height is configured to effect a predetermined range of initial drainage flow rates during the open configuration mode.
4 more elements
Dependencies are inferred from the claim text.