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US 11,819,517 B2Granted
Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
AssigneeIovance Biotherapeutics, Inc.
InventorMaria Fardis
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Abstract
Methods of treating melanomas refractory to other therapies using tumor infiltrating lymphocytes are disclosed.
Claims15
A method of treating double-refractory metastatic melanoma in a patient in need thereof, the method comprising administering a therapeutically effective population of tumor infiltrating lymphocytes (TILs) to the patient, wherein the metastatic melanoma is resistant to a) a PD-1 inhibitor or a PD-L1 inhibitor, and b) a BRAF inhibitor or a combination of a BRAF inhibitor and a MEK inhibitor.
Dependencies are inferred from the claim text.