Retinoid derivatives with antitumor activity
AssigneeBiogem S.C. A R.L.
InventorsClaudio Pisano, Sabrina Dallavalle, Raffaella Cincinelli, Lucio Merlini
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.
Claims20
A method for treating an altered angiogenesis comprising administration to an individual in need thereof a medicament or pharmaceutical composition comprising:
- (a) 3-(3′-adamantan-1-yl-4′-hydroxycarbamoylmethoxybiphenyl-4-yl)-acrylic acid (MIR002);
- (b) 3-[3′-adamantan-1-yl-4′-(1-hydroxycarbamoylethoxy)-biphenyl-4-yl]-acrylic acid (GEM144);
- or
- (c) a combination of (a) and (b).
A method for treating a disease selected from the group consisting of an arthritic pathology, a tumor, a metastatization, diabetic retinopathy, psoriasis and chronic inflammatory disease,
- the method comprising administration to an individual in need thereof a medicament or pharmaceutical composition comprising:
- (a) 3-(3′-adamantan-1-yl-4′-hydroxycarbamoylmethoxybiphenyl-4-yl)-acrylic acid (MIR002);
- (b) 3-[3′-adamantan-1-yl-4′-(1-hydroxycarbamoylethoxy)-biphenyl-4-yl]-acrylic acid (GEM144);
- or
- (c) a combination of (a) and (b).
Dependencies are inferred from the claim text.