Hemostatic paste and methods of making thereof
AssigneesGuangzhou Bioseal Co., Ltd., Johnson & Johnson China Ltd., Ethicon, Inc.
InventorsDengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
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Abstract
The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
Claims5
A method of making a flowable hemostatic paste comprising the steps of:
- a. Cross-linking carboxymethyl cellulose (CMC) by reaction CMC with an acid at an elevated temperature;
- b. Substantially drying the cross-linked CMC to form an xerogel;
- c. Milling the cross-linked CMC xerogel to a powder having average particle size of less than 100 microns;
- d. Adding at least one selected alcohol-functionalized dispersant and a glycerol-containing dispersant to the CMC xerogel and
- e. Mixing to form said flowable hemostatic paste.
A method of making a wound dressing containing a hemostatic paste, comprising the steps of applying said hemostatic paste onto at least one face of a flexible bioabsorbable sheet substrate, wherein said paste comprises:
- a xerogel cross-linked milled polysaccharide dispersed within a substantially anhydrous blend of a glycerol-containing dispersant and an alcohol-functionalized dispersant selected from the group consisting of propylene glycol and 1,3-Butanediol or mixtures thereof, wherein the paste has a moderate viscosity at rest and room temperature and provides a substantially homogenous dispersion of the crosslinked polysaccharide, and wherein said cross-linked polysaccharide is a suspended powder having average particle size less than 100 microns.
A method of using a hemostatic paste, comprising the steps of applying said hemostatic paste, optionally supported on a flexible absorbable sheet substrate, to a bleeding tissue or wound, wherein said paste comprises:
- a xerogel cross-linked milled polysaccharide dispersed within a substantially anhydrous blend of a glycerol-containing dispersant and an alcohol-functionalized dispersant selected from the group consisting of propylene glycol and 1,3-Butanediol or mixtures thereof, wherein the paste has a moderate viscosity at rest and room temperature and provides a substantially homogenous dispersion of the crosslinked polysaccharide, and wherein said cross-linked polysaccharide is a suspended powder having average particle size less than 100 microns.
Dependencies are inferred from the claim text.