Lithium disilicate glass-ceramic compositions and methods thereof

A bioactive composition, comprising:

• a glass-ceramic composition comprising
• a first crystalline phase comprising lithium disilicate, and
• a second crystalline phase that is apatite, wollastonite, fluorapatite, cristobalite, β-quartz, lithiophosphate, or a combination thereof;
• and
• at least one live osteoblast cell,
• wherein contacting the bioactive composition with a liquid medium produces proliferation of the osteoblast cell on a surface of the bioactive composition, and
• wherein the glass-ceramic composition comprises a source of:
• 50 to 75 wt % SiO2,
• 1 to 5 wt % Al2O3,
• 1 to 8 wt % P2O5,
• 2 to 10 wt % CaO,
• 5 to 20 wt % Li2O,
• 0.5 to 5 wt % Na2O,
• 0.5 to 8 wt % ZrO2,
• 0.1 to 10 wt % B2O3, and
• 0.1 to 1.0 wt % F−, based on a 100 wt % total of the composition.