Methods for disproportionation quenching of ozonides
AssigneeP2 Science, Inc.
InventorsAlexander Kendall, Yonghua Yang, Patrick Foley
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Abstract
The present disclosure provides improved methods of performing ozonolysis on alkenes comprising non-reductive quenching of ozonide intermediates using Bronsted bases to yield aldehyde, ketone and/or carboxylic acid products.
Claims11
A method of non-reductive quenching of ozonides using Bronsted bases to yield aldehyde and carboxylic acid, or ketone and carboxylic acid products, wherein the method comprises (a) reacting an alkene with ozone to generate a secondary ozonide intermediate, and (b) quenching the ozonide by adding an alkali metal or alkaline earth metal hydroxide, carbonate, bicarbonate, sulfate or phosphate to the ozonide in a C2-C12 carboxylic acid solvent with water co-solvent to form the corresponding alkali metal or alkaline earth metal salt of the C2-C12 carboxylate salt Bronsted base in-situ, to yield the aldehyde and carboxylic acid products, or the ketone and carboxylic acid products;
- and
- wherein step (b) does not comprise a reducing agent and/or an oxidizing agent.
Dependencies are inferred from the claim text.