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US 11,813,311 B2Granted
Treatment and prevention of metabolic diseases
AssigneesSingapore Health Services Pte Ltd, National University of Singapore
InventorsStuart Alexander Cook, Sebastian Schaefer, Brijesh Kumar Singh, Anissa Widjaja
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Abstract
Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
Claims8
A method of treating a metabolic disease, comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject;
- wherein the agent is selected from:
- (i) an anti-IL-11 antibody antagonist of IL-11-mediated signalling, or an antigen-binding fragment thereof, or (ii) an anti-IL-11Rα antibody antagonist of IL-11-mediated signalling, or an antigen-binding fragment thereof;
- and wherein the metabolic disease is or comprises:
- obesity, being overweight, hyperglycaemia, pregnancy-associated hyperglycemia, insulin resistance, pre-diabetes, metabolic syndrome, hyperlipidaemia, hypertriglyceridemia, hypercholesterolemia, pancreatic insufficiency, pancreatitis, acute pancreatitis, chronic pancreatitis, lipotoxicity, or hyperglucagonemia.
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Dependencies are inferred from the claim text.