Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50, and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsSoumitra Roy, James M. Wilson, Luc H. Vandenberghe
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Abstract
A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Claims16
A recombinant adenovirus having an adenovirus capsid comprising a hexon protein, a penton protein, and a fiber protein, wherein said hexon protein is a hexon protein of SAdV-47 comprising amino acids 1 to 958 of SEQ ID NO:
- 109
- said capsid encapsidating a heterologous nucleic acid comprising a gene operably linked to expression control sequences which direct at least one of transcription, translation, and expression of the gene in a host cell.
A recombinant adenovirus having a capsid comprising a fiber protein, a penton protein, and a hexon protein, said hexon protein comprising (a) a full-length of amino acids about 51 to 958 of SEQ ID NO:
- 109 or (b) the full length of amino acids 1 to about 908 of SEQ ID NO:
- 109, said adenovirus capsid encapsidating a gene heterologous to SAdV-47 operably linked to expression control sequences which direct at least one of transcription, translation, and expression of the gene in a host cell.
Dependencies are inferred from the claim text.