Antibody fusion protein and related compositions for targeting cancer
AssigneesDignity Health, Arizona Board of Regents on behalf of Arizona State University
InventorsRachael Sirianni, Rebecca Cook, Tsafrir Mor, Joseph Blattman
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Abstract
Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
Claims16
A method of treating cancer in a subject, comprising:
- providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain comprises a chlorotoxin peptide and/or a chlorotoxin-like peptide and is capable of binding to a cancer cell;
- wherein the composition includes a sequence comprising SEQ ID NO:
- 9. SEQ ID NO:
- 10, SEQ ID NO:
- 11, or SEQ ID NO:
- 12;
- and
- treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
Dependencies are inferred from the claim text.