Synthesis of novel ketone body analogs for use as a nutritional supplement
OwnerSamuel J. Rozzoni, Daryl R. Sauerinventors
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Abstract
When a healthy and balanced diet is not achieved, nutritional supplements are used to help deal with the resulting health issues and enhance the body's performance. The present invention relates to a novel category of molecules that combine the properties of both ketone bodies and β-Hydroxy β-Methylbutyrate (HMB) that can be used as supplements for treating a wide range of health-related issues. Acetoacetate and β-Hydroxybutrate along with isopentyldiol were used as the sources of ketone bodies and HMB, respectively. The present invention provides a method of synthesis for a new group of compounds that incorporate the properties found in acetoacetate and 3-hydroxybutyrate molecules with that of β-hydroxy β-methylbutyrate.
Claims20
A compound having the formula:
- wherein either R1 or R2 is hydrogen, and R1 or R2 cannot be hydrogen at the same time;
- when R2 is hydrogen, R1 is a structural composition selected from the group consisting of:
- Acetoacetyl (CH3COCH2CO—), β-Hydroxybutyryl (CH3CH(OH)CH2CO—), (R)-β-Hydroxybutyryl or (S)-β-Hydroxybutyryl;
- and
- when R1 is hydrogen, R2 is a structural composition selected from a group consisting of:
- Acetoacetyl (CH3COCH2CO—), β-Hydroxybutyryl (CH3CH(OH)CH2CO), (R)-β-Hydroxybutyryl (CH3CH(OH)CH2CO—) or (S)-β-Hydroxybutyryl (CH3CH(OH)CH2CO—);
- and
- any salt, ester, or polymer thereof.
A compound having the formula:
- wherein either R1 or R2 is hydrogen, and R1 or R2 cannot be hydrogen at the same time;
- when R2 is hydrogen, R1 is a structural composition selected from the group consisting of:
- Acetoacetyl (CH3COCH2CO—), β-Hydroxybutyryl (CH3CH(OH)CH2CO—), (R)-β-Hydroxybutyryl or (S)-β-Hydroxybutyryl;
- and
- when R1 is hydrogen, R2 is a structural composition selected from a group consisting of:
- Acetoacetyl (CH3COCH2CO—), β-Hydroxybutyryl (CH3CH(OH)CH2CO), (R)-β-Hydroxybutyryl (CH3CH(OH)CH2CO—) or (S)-β-Hydroxybutyryl (CH3CH(OH)CH2CO—).
A compound having the formula:
A compound having the formula:
A compound having the formula:
A compound having the formula:
A compound having the formula:
A compound having the formula:
Dependencies are inferred from the claim text.