Compositions and devices of poly-4-hydroxybutyrate
AssigneeTepha, Inc.
InventorsDavid P. Martin, Simon F. Williams, Kai Guo
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Abstract
Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues.
Claims28
A composition comprising a polyhydroxyalkanoate polymer that has been extracted and purified from a biomass, wherein the composition comprises at least 97.7% polyhydroxyalkanoate polymer by weight as determined by gas chromatography, wherein the polyhydroxyalkanoate polymer has a weight average molecular weight that ranges from 20 kDa to 200 kDa, and wherein the composition has:
- (i) a nitrogen content of less than 40 ppm, (ii) a sulfur content of less than 50 ppm, and (iii) a heavy metal content of less than 20 ppm.
A composition comprising a polyhydroxyalkanoate polymer derived from a biomass, wherein the polyhydroxyalkanoate polymer has a weight average molecular weight that ranges from 20 kDa to 200 kDa, and wherein the composition has:
- (i) a nitrogen content of less than 40 ppm, (ii) a sulfur content of less than 50 ppm, and (iii) a heavy metal content of less than 20 ppm, wherein the composition is produced by washing the biomass comprising the polymer with ethanol.
Dependencies are inferred from the claim text.