# US 11,806,415 B2 · Hypochlorous acid-based eyelid cleansers > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,806,415 B2 - Document ID: US11806415B2 - Status: Granted - Kind: B2 - Application number: 17/401,777 - Filed: 2021-08-13 - Published: 2021-12-02 - Granted: 2023-11-07 - Earliest claimed: 2018-05-02 - Assignees: OCuSOFT, Inc. - Applicants: OCuSOFT, Inc. - Inventors: Nat Adkins, Jr.; Cynthia Barratt; Thomas Mason; Paramita Sarkar - Web page: https://patentgrep.com/patent/US11806415B2 ## CPC - A61K 8/20: Halogens; Compounds thereof - A61Q 1/14: Preparations for removing make-up - A61K 8/0208: {Tissues; Wipes; Patches} - A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids - A61K 8/86: Polyethers - A61Q 17/005: {Antimicrobial preparations} - A61Q 19/10: Washing or bathing preparations - A61K 2800/522: Antioxidants; Radical scavengers - A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18 - A61K 2800/87: Application Devices; Containers; Packaging - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract An antimicrobial eyelid cleanser composition contains: (a) a hypohalous acid; (b) one or more surfactants having a HLB value of 5 to 18; and (c) an aqueous vehicle, the aqueous vehicle comprising: (i) one or more tonicity adjusters; (ii) one or more osmolality adjusters for adjusting an osmolality of the composition; and (iii) one or more pH adjusters for maintaining the pH of the composition at between about 4.5 to about 8.0. The composition can be dispensed in a foam, liquid, spray, mist, gel or lotion form. The composition can facilitate long term eyelid hygiene by removing excess oil, debris and desquamated skin and provide relief for inflammation of the eyes. ## Claims ### Claim 1 A topical eyelid cleanser composition comprising: (a) 50 to 300 ppm hypochlorous acid; (b) two or more surfactants, wherein: (i) a first surfactant has an HLB value from 10 to 18, and (ii) a second surfactant has an HLB value from 5 to 10, and (c) deionized water or purified water USP, wherein the total concentration of the two or more surfactants is in the range of 0.01%-20% w/w. ### Claim 2 (depends on 1) The eyelid cleanser composition according to claim 1, wherein the one or more surfactants is selected from the group consisting of sorbitan, sorbitan monolaurate, polyoxyethylene, polyethylene glycol (PEG)-modified surfactants, PEG-modified phospholipids, PEG-modified sugars, amineoxides, block copolymers and mixtures thereof. ### Claim 3 (depends on 1) The eyelid cleanser composition according to claim 1, wherein the aqueous vehicle includes one or more tonicity adjusters selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium lactate, potassium lactate, calcium lactate and mixtures thereof. ### Claim 4 (depends on 1) The eyelid cleanser composition according to claim 1, wherein the aqueous vehicle includes one or more osmolality adjusters selected from the group consisting of sugars, glycerin, propylene glycol and mixtures thereof. ### Claim 5 (depends on 1) The eyelid cleanser composition according to claim 1, wherein the aqueous vehicle includes one or more buffering components selected from the group consisting of phosphate salts, citrate salts, and tris salts mixed with their corresponding acids/bases in defined ratios to adjust a pH of the composition to between about 5.0 to about 7.0, and mixtures thereof. ### Claim 6 (depends on 1) The eyelid cleanser composition according to claim 1, wherein the one or more surfactants are selected from the group consisting of nonionic and amphoteric surfactants. ### Claim 7 (depends on 1) The eyelid cleanser composition according to claim 1, wherein a total concentration of the one or more surfactants in the composition is in the range of 0.01-5% w/w. ### Claim 8 (depends on 1) The eyelid cleanser composition according to claim 1, further comprising a foam stabilizer, wherein the foam stabilizer is a polyethylene glycol diester of methyl glucose and a fatty acid. ### Claim 9 (depends on 1) The eyelid cleanser composition according to claim 1, further comprising 0.01-5% w/w of one or more ingredients selected from the group consisting of propylene glycol, glycerin, liquid polyols, nut oils and derivatives, floral extracts, fruit extracts, sodium alginate, hyaluronic acid, diglycerides, triglycerides, PEG-75 Lanolin, mineral oil, silicone oil and mixtures thereof. ### Claim 10 (depends on 1) The eyelid cleanser composition according to claim 1, further comprising 0.01-5% w/w of one or more ingredients selected from the group consisting of an antioxidant, an anti-irritant, a cooling agent, a viscosity modifier and mixtures thereof. ### Claim 11 (depends on 1) A kit for maintaining eyelid hygiene, wherein the kit consists essentially of an applicator pre-moistened with a clinically effective amount of the topical eyelid cleanser composition according to claim 1. ### Claim 12 (depends on 11) The kit for maintaining eyelid hygiene according to claim 11, wherein the applicator comprises one or more fabric pads. ### Claim 13 (depends on 1) A method for managing eyelid care, the method comprising the application of an effective amount of the eyelid cleanser composition according to claim 1 to the eyelids and its surrounding areas. ### Claim 14 (depends on 1) An eyelid cleansing kit consisting essentially of a: an applicator, wherein the applicator is saturated with an effective amount of the eyelid cleanser composition according to claim 1. ### Claim 15 (depends on 14) The eyelid cleansing kit according to claim 14, wherein the applicator is a fabric pad/wipe. ### Claim 16 (depends on 15) The eyelid cleansing kit according to claim 15, wherein the fabric pad/wipe comprises a hypoallergenic, non-woven, hydrophilic material. ### Claim 17 (depends on 15) The eyelid cleansing kit according to claim 15, wherein the fabric pad/wipe is configured as a single use, disposable pad/wipe. ### Claim 18 (depends on 15) The eyelid cleansing kit according to claim 15, wherein the fabric pad/wipe is individually packaged in a sealable package. ### Claim 19 (depends on 18) The eyelid cleansing kit according to claim 18, wherein the kit includes 1-100 individually sealed packages.